Female Female.
4
2015-11-04
2x risk of Alzheimer's disease You carry one APOE-ε3 allele and one APOE-ε4 allele. This results in 2x-3x increased relative risk of Alzheimer's disease compared to those carrying two APOE-ε3 alleles. For non-Caucasians the risk is increased, but SNPedia has not yet seen any reliable estimates. This is based on
• rs429358(C;T)
• rs7412(C;C)

Community
Learning while you are healthy that your odds of developing Alzheimer's may be higher than average by the time you are 80 years old can be a shock. Some of the people who have learned about their higher risk have formed ApoE4.info, a non-profit for ApoE4 carriers to discuss research and provide support. This includes a research wiki and a discussion forum. Genoset gs216 identifies carriers of two ApoE-ε4 alleles.
Bad
3.5
2018-05-07
Alzheimer's disease
Blue eyes are more likely Most people with this have some shade of blue eye color (some are more grey, some are more green), however one person with brown eyes claims also to have observed this genoset. This spreadsheet is gathering more information on self-reported eye color. File:Lilly_Mendel_blue_eyes.JPG File:Reyes.jpg File:KarenToboEyes.jpg File:Eyes.jpg
3.1
2017-12-13
Fully heterozygous, age-related tasting variation You are heterozygous at all 3 of the SNPs known to influence the ability to taste bitterness. This means you are better than average at detecting bitter tastes while young, but that this ability decreases to less than average during adulthood. As a child, you will probably hate Brussels sprouts, and by early adulthood will discover that olives and Brussels sprouts now taste good. A 2010 study shows the change bitter sensitivity which occurs over the lifespan (from bitter sensitive to less so) is more common in people with this genoset. Children with this genotype could perceive a bitter taste at lower PROP concentrations than could heterozygous adults. The threshold for adolescents was intermediate. The 3 SNPs are rs10246939, rs1726866, rs713598 in the gene TAS2R38.
3
2017-06-03
Taste
Mitochondrial Haplogroup H3 European maternal ancestry. Mitochondrial Haplogroup H3 represents a smaller fraction of European genome than H1 but has a somewhat similar distribution with peak among Basques (13.9%), Galicians (8.3%) and Sardinians (8.5%). Its importance decreases towards the northeast of the continent

See Also

• Haplogroup_H_(mtDNA)
• i1000015
• i3001487

Links

• Ian Logan's mtDNA Website
• Wikipedia mtDNA
3
2011-01-08
1.5x - 2x increased risk for cervical cancer, HNSCC, and breast cancer
rs3738579 represents a SNP in the 5' UTR region upstream of the RNASEL gene. A study of patients diagnosed with carcinoma of the uterine cervix, head and neck squamous cell carcinomas (HNSCC), and breast cancer found 1.5x-2x increased risk for all three cancer types for the rs3738579(T;T) genotype, while finding decreased risk (0.5x) for rs3738579(C;T) heterozygotes. rs3738579(C;C) homozygotes had 0.6x less risk for cervical cancer but increased risk for HNSCC (1.4x) and breast cancer (1.8x). Although statistics were not reported per genotype, a combination of data from all three cancer forms over all genotypes provided strong statistical evidence for rs3738579 as a cancer marker, with a p-value of 4.43x10(-5).
more info
Bad
3
38.1%
TSIMKKMEXLWKGIHCHDASWYRIJPTHCBCEU0255075100
2013-11-07
0.2392
1
RNASEL
1
182586901
3
2018-12-05
minus
minus
Breast cancer Cancer
likely to be a carrier of one HLA-B27 allele, possible risk for B27 Syndromes. See details at: HLA-B27.
Not all allelles of HLA-B27 are at risk for B27 Syndromes, please check the HLA-B27 page for details.
See: HLA-B27. Not all alleles of HLA-B27 are at risk for B27 Syndromes, please check the HLA-B27 page for details.
more info
Bad
3
10.6%
TSIMKKMEXLWKGIHCHDASWYRIJPTHCBCEU0255075100
2016-05-29
0.06152
2
6
31376806
3
2017-09-03
plus
plus
HLA
reduced MAOA activity
rs6323 (R297R / Arg297Arg) is a SNP in the MAOA (monoamine oxidase A) gene. Monoamine oxidase A degrades serotonin, dopamine, epinephrine, and norepinephrine. The G allele encodes for the higher activity form of the enzyme. Subjects with major depressive disorder with the highest activity form of the enzyme (G or G/G) had a significantly lower magnitude of placebo response.
more info
3
65.5%
TSIMKKMEXLWKGIHCHDASWYRIJPTHCBCEU0255075100
2015-12-23
0.3319
Other
14
MAOA
X
43731789
3
2019-01-31
plus
plus
ClinVar Other not specified
1.42x risk of Autism Worse cell adhesion in neurons. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008767/ Increased risk of Autism Spectrum Disorders.
23andMe blog rs4307059— compared to two copies of a C, each copy of the more common T version increased the odds of autism by 1.19 times. http://dx.doi.org/10.1038/nature07999
more info
Bad
3
38.1%
TSIMKKMEXLWKGIHCHDASWYRIJPTHCBCEU0255075100
2013-10-09
0.2365
7
5
25967594
3
2018-12-05
plus
plus
Autism
Lack of empathy? You have a SNP in the oxytocin receptor which may make you less empathetic than other people. When under stress you may have more difficulty recognizing the emotional state of others which impacts loneliness, parenting, and socializing skills. Some studies have suggested that the A;G genotype is associated with an intermediate level of empathy (compared to the G;G and A;A genotypes), although most report that A;G and A;A individuals have similar levels of empathy and stress handling capabilities.
rs53576 is a silent G to A change in the oxytocin receptor (OXTR) gene. Studies have demonstrated that individuals with the G allele are more empathetic, feel less lonely, employ more sensitive parenting techniques, and have lower rates of autism (discussed in) The blog Not Exactly Rocket Science discusses that Americans with (G;G) tend to be more sensitive parents, more empathetic and less lonely than those with an‘A’. In a Korean population people with (G;G) were less likely to seek support from their peers. Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. In brief, people with the G;G genotype were better able to discern the emotional state of others than those who carried the A-allele (...
more info
Bad
2.8
2018-01-24
0.4128
53
OXTR
3
8762685
2.8
2019-02-03
plus
plus
Personality

ABO blood group predictions are brand new, and still under development. We're rolling it out to you so we can see how it performs on real data. All conclusions are still greatly limited by the general lack of phased data, the lack of genotyping at all of the necessary snps, and other factors.

best guess:

ABO blood type
O

rs8176719(D;D)
rs8176746(C;C)
rs8176747(G;G)
rs8176719 (D;D) indicates you are type-O
you were not genotyped at either rs590787 nor i4001527 so it is impossible to see your Rh blood type

But the ABO system is quite limited

Blood, you see, doesn't just come in types A, B, AB, and O. The "positive" or "negative?" Nope. In fact, let's get all the way into the weeds: Scientists have since discovered over 300 proteins that contribute to blood type. The AB+ on your blood donor card? Yeah, that's a massive oversimplification... read more at Beyond Blood Type: Genomics Can Show What You're Really Made Of

or

It would be straightforward if we all had the same blood. But we don't. On the surface of every one of our red blood cells, we have up to 342 antigens - molecules capable of triggering the production of specialised proteins called antibodies. It is the presence or absence of particular antigens that determines someone's blood type.

Some 160 of the 342 blood group antigens are 'high-prevalence', which means that they are found on the red blood cells of most people. If you lack an antigen that 99 per cent of people in the world are positive for, then your blood is considered rare. If you lack one that 99.99 per cent of people are positive for, then you have very rare blood.

If a particular high-prevalence antigen is missing from your red blood cells, then you are 'negative' for that blood group. If you receive blood from a 'positive' donor, then your own antibodies may react with the incompatible donor blood cells, triggering a further response from the immune system. These transfusion reactions can be lethal. Read more at The man with the golden blood.

Known ABO SNPs

23andMe ABO
IndexGeneSNPGenoReputeMagnitudeSummary
1   rs7466519 not tested
2   rs8176750 (I;I)    
3   rs56202119 not tested
4   i4000505 (G;G) Good 0
5   rs56231718 not tested
6   rs55788852 not tested
7   rs55927860 not tested
8   rs8176749 (G;G)   0
9   rs56190619 not tested
10   rs55783488 not tested
11   rs56355240 not tested
12   i4000504 (C;C)   0
13   rs56409303 not tested
14   rs55805279 not tested
15   rs56106480 not tested
16   rs8176747 (G;G) Good 0 common in clinvar
17   rs41302905 (C;C) Good 0 common in complete genomics
18   rs8176746 (C;C)   0
19   rs8176745 not tested
20   rs55951833 not tested
21   rs8176743 (G;G)   0
22   i5007173 not tested
23   rs55739900 not tested
24   rs56116432 not tested
25   rs56031507 not tested
26   rs8176741 (C;C)    
27   rs56408700 not tested
28   rs8176740 (A;T)    
29   rs55827808 not tested
30   rs8176739 not tested
31   rs56223957 not tested
32   rs56189011 not tested
33   rs56089890 not tested
34   rs55727303 not tested
35   rs7853989 (G;G)     Not blood group B
36   rs55964869 (C;C) Good 0 common in complete genomics
37   rs55756402 not tested
38   i5007171 not tested
39   rs1053878 (C;C) Good 0 common in complete genomics
40   rs55658842 not tested
41   rs7873522 not tested
42   rs8176732 not tested
43   rs2073824 (A;G)    
44   rs8176722 (G;G)    
45   rs8176721 not tested
46   rs8176720 (A;G)    
47   rs8176719 (D;D)     likely to be of blood type O
48   rs56231711 not tested
49   rs8176717 not tested
50   rs512770 (A;G)    
51   rs641959 not tested
52   rs514708 not tested
53   rs55958637 not tested
54   rs549446 not tested
55   rs8176704 (C;C)    
56   rs574347 (C;T)    
57   rs688976 not tested
58   rs687289 (C;C)    
59   rs2073828 (A;G)    
60   rs55876802 not tested
61   rs8176694 (A;A)    
62   rs672316 not tested
63   rs657152 (G;G) Good 0 common/normal
64   rs8176682 not tested
65   rs474279 not tested
66   rs500498 (T;T)    
67   rs505922 (T;T) Good 2 blood type O
68   rs507666 (G;G)    
69   rs630014 (C;T)    
SNPedia ABO
IndexGeneSNPGenoReputeMagnitudeSummary
1   rs1053878 (C;C) Good 0 common in complete genomics
2   rs2073824 (A;G)    
3   rs2073828 (A;G)    
4   rs2519093 not tested
5   rs41302905 (C;C) Good 0 common in complete genomics
6   rs500498 (T;T)    
7   rs505922 (T;T) Good 2 blood type O
8   rs507666 (G;G)    
9   rs512770 (A;G)    
10   rs514659 not tested
11   rs55722397 not tested
12   rs55964869 (C;C) Good 0 common in complete genomics
13   rs56392308 not tested
14   rs574347 (C;T)    
15   rs612169 not tested
16   rs630014 (C;T)    
17   rs643434 not tested
18   rs644234 not tested
19   rs657152 (G;G) Good 0 common/normal
20   rs687289 (C;C)    
21   rs687621 not tested
22   rs7853989 (G;G)     Not blood group B
23   rs8176694 (A;A)    
24   rs8176704 (C;C)    
25   rs8176719 (D;D)     likely to be of blood type O
26   rs8176720 (A;G)    
27   rs8176722 (G;G)    
28   rs8176740 (A;T)    
29   rs8176741 (C;C)    
30   rs8176743 (G;G)   0
31   rs8176746 (C;C)   0
32   rs8176747 (G;G) Good 0 common in clinvar
33   rs8176749 (G;G)   0
34   rs8176750 (I;I)